Predictive Factors for Relapse in Children with Steroid Responsive Nephrotic Syndrome.
- Author:
Min Hyun CHO
1
;
Dong Won LEE
;
Tae Ho LEE
;
Cheol Woo KO
Author Information
1. Department of Pediatrics, College of Medicine, Pochon CHA University, Kumi CHA Medical Center, Kumi, Korea.
- Publication Type:Original Article
- Keywords:
Steroid responsive nephrotic syndrome;
Predictive factors;
Relapse
- MeSH:
Biopsy;
Child*;
Diagnosis;
Female;
Gyeongsangbuk-do;
Hematuria;
Humans;
Male;
Medical Records;
Nephrosis, Lipoid;
Nephrotic Syndrome*;
Pediatrics;
Recurrence*;
Retrospective Studies
- From:Journal of the Korean Society of Pediatric Nephrology
2005;9(2):167-174
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Relapses are a major problem in children with steroid responsive nephrotic syndrome(SRNS). This study has been performed to determine the predictive factors for relapse in children with SRNS. METHODS: The study group consisted of 73 children with SRNS who had been admitted to the Department of Pediatrics, Kyungpook National University Hospital, over 6 years from 1996 to 2001. The medical records were reviewed retrospectively and analyzed to determine significant relationships between selected variables[age at onset, sex, laboratory data, the rapidity of response(days to remission), interval to first relapse] and the frequency of relapse. RESULTS: The age(mean+/-SD) of patients was 4.53+/-2.53 years old. The male to female ratio was 52:21. In 95%, 39 out of the 41 children had a renal biopsy, and the final diagnosis was minimal change nephrotic syndrome. There was no significant correlation between the frequency of relapse and the following variables:age at onset, sex, and presence of hematuria. However, the rapidity of response correlated well with the frequency of relapse, especially during the first year after the onset of the disease(P=0.006). CONCLUSION: The rapidity of response is expected to be one of the predictive factors for relapse in children with SRNS.
