Alteration of Nerve Growth Factor in the Penis of Rats with Streptozotocin-induced Diabetes.
- Author:
Jin Seon CHO
1
;
In RYU
;
Kyung Ahn KIM
;
Sang Kon LEE
;
Young Euy PARK
Author Information
1. Department of Urology, College of Medicine, Hallym University, Chunchon, Korea.
- Publication Type:Original Article
- Keywords:
NGF;
Diabetes;
Streptozotocin;
Neuropathy;
Penis;
Impotence
- MeSH:
Animals;
Diabetic Neuropathies;
Enzyme-Linked Immunosorbent Assay;
Erectile Dysfunction;
Insulin;
Male;
Molecular Structure;
Nerve Growth Factor*;
Penis*;
Physiology;
Rats*;
Streptozocin;
Weight Gain
- From:Korean Journal of Urology
1995;36(1):23-27
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Insulin and nerve growth factor (NGF) share several properties concerning physiological activity, molecular structure and site of synthesis. Considering the properties that NGF shares with insulin, and the important role it plays on nerve physiology, NGF may participate in the pathophysiology of diabetic neuropathy. We investigated the alterations of NGF in the penis of diabetic rats at 8-week after induction of diabetes with streptozotocin. NGF was determined by sandwich ELISA method. The weight gain reduced significantly in diabetic rats. Diabetic rats showed a significantly reduced NGF content in the penis (62.3% of control, p<0.05 at 8-week after induction of diabetes. These findings suggest that decreased NGF levels in the penis of diabetic rats may be involved in the development of the diabetic neuropathy regarded as important cause of diabetic impotence.
