Apolipoprotein epsilon4 and Cognitive Function, Daily Living Ability and Behavioral Symptoms of Dementia.
- Author:
Young Don KIM
1
;
Chang Hwa LEE
;
Ki Choon EUM
;
Dong Hee KIM
;
Kyeong Sik YOON
Author Information
1. Department of Psychiatry, College of Medicine, Eulji University, Daejeon, Korea. ydkim@sunhospital.com
- Publication Type:Original Article
- Keywords:
Dementia;
Apolipoprotein epsilon4;
Multidimensional measures
- MeSH:
Apolipoproteins*;
Behavioral Symptoms*;
Dementia*;
Genotype;
Humans;
Korea;
Polymerase Chain Reaction;
Polymorphism, Restriction Fragment Length
- From:Journal of Korean Geriatric Psychiatry
2002;6(1):49-56
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We investigated the relationship between apolipoprotein epsilon4 and clinical features of dementia. METHODS: Samples were obtained from 33 dementia patients in Korea, Buyeo Geriatric Hospital and apolipoprotein E polymorphisms were analysed using polymerase chain reaction and restriction fragment length polymorphism. The multidimensional evaluating methods (MMSE-K, B-ADL, BEHAVE-AD, GDS, GMHR) for dementia were performed to analyze relationship with Apolipoprotein E genotypes. RESULTS: The distributions of the apolipoprotein E genotypes of the dementia patients were presented by epsilon3/epsilon3 (58%), epsilon3/epsilon4 (22%), epsilon2/epsilon3 (15%), and epsilon4/epsilon4 (0%). There is no significant relationship between apolipoprotein epsilon4 and the findings of multidimensional evaluating measures. CONCLUSION: We could not find the association between apolipoprotein epsilon4 and the scores of the multidimensional evaluating measures of dementia patients. The results suggested that apolipoprotein epsilon4 might not play a main role in cognitive function, daily living ability and behavioral symptoms of dementia.
