Molecular Mechanisms of Appetite Regulation.
10.4093/dmj.2012.36.6.391
- Author:
Ji Hee YU
1
;
Min Seon KIM
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. mskim@amc.seoul.kr
- Publication Type:Review
- Keywords:
Adiposity;
Appetite;
Hypothalamus;
Leptin;
Satiety
- MeSH:
Adiposity;
Appetite;
Appetite Regulation;
Brain;
Brain Stem;
Cholecystokinin;
Developed Countries;
Eating;
Endocannabinoids;
Feeding Behavior;
Ghrelin;
Glucagon-Like Peptide 1;
Hunger;
Hypothalamus;
Insulin;
Leptin;
Obesity;
Oxyntomodulin;
Pancreatic Polypeptide;
Peptide YY;
Prevalence
- From:Diabetes & Metabolism Journal
2012;36(6):391-398
- CountryRepublic of Korea
- Language:English
-
Abstract:
The prevalence of obesity has been rapidly increasing worldwide over the last several decades and has become a major health problem in developed countries. The brain, especially the hypothalamus, plays a key role in the control of food intake by sensing metabolic signals from peripheral organs and modulating feeding behaviors. To accomplish these important roles, the hypothalamus communicates with other brain areas such as the brainstem and reward-related limbic pathways. The adipocyte-derived hormone leptin and pancreatic beta-cell-derived insulin inform adiposity to the hypothalamus. Gut hormones such as cholecystokinin, peptide YY, pancreatic polypeptide, glucagon-like peptide 1, and oxyntomodulin transfer satiety signals to the brain and ghrelin relays hunger signals. The endocannabinoid system and nutrients are also involved in the physiological regulation of food intake. In this article, we briefly review physiological mechanisms of appetite regulation.
