Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group.
- Author:
Juan Carlos LOPEZ-ALVARENGA
1
;
William ORR
;
Jose Antonio VARGAS-ROMERO
;
Jose Maria REMES-TROCHE
;
Miguel MORALES-ARAMBULA
;
Julio Cesar SOTO-PEREZ
;
Gualberto MATEOS-PEREZ
;
Sergio SOBRINO-COSSIO
;
Oscar TERAMOTO-MATSUBARA
;
Aurelio LOPEZ-COLOMBO
;
Antonio OROZCO-GAMIZ
;
Adolfo SAEZ-RIOS
;
Araceli ARELLANO-PLANCARTE
;
Jazmin CHIU-UGALDE
;
Anne THOLEN
;
Silke HORBACH
;
Lars LUNDBERG
;
Ronnie FASS
Author Information
1. Direccion de Investigacion, Hospital General de Mexico OD, Mexico City, Mexico. jclalvar@yahoo.com
- Publication Type:Original Article
- Keywords:
Gastroesophageal;
Night-time symptoms;
Pantoprazole;
Proton pump inhibitors
- MeSH:
Arousal;
Gastroesophageal Reflux*;
Heartburn;
Humans;
Magnesium*;
Mexico;
Observational Study;
Prospective Studies;
Proton Pump Inhibitors;
Surveys and Questionnaires
- From:Journal of Neurogastroenterology and Motility
2014;20(1):64-73
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and extra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms. METHODS: Patients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other symptom in the last week were enrolled in a nationwide, prospective and observational study in Mexico. Patients received pantoprazole-Mg 40 mg once daily during 4 weeks. Symptoms were assessed through a physician-administered structured interview and the patient-completed ReQuest in Practice(TM) questionnaire. Night-time GERD was defined as arousal from sleep during the night due to GERD-associated symptoms. RESULTS: Out of 4,343 patients included at basal visit, 3,665 were considered for the effectiveness per protocol analysis. At baseline, patients had a median of 8 GERD related symptoms. Patients with night-time GERD symptoms (42.7%) were more likely to have extra-esophageal symptoms (P < 0.001) than other GERD patients. Pantoprazole-Mg 40 mg once daily for 4 weeks improved a broad range of GERD-associated symptoms from baseline (80% reduction on physicians assessments; 68-77% reduction on ReQuest in Practice(TM) dimensions), including both day- and night-time GERD symptoms; improvements were the greatest for extra-esophageal symptoms in patients with night-time symptoms. Pantoprazole-Mg was well tolerated. CONCLUSIONS: Pantoprazole-Mg 40 mg significantly improved a broad range of esophageal and extra-esophageal GERD related symptoms including sleep disturbances, as well as well-being, in patients with daytime or night-time GERD, making it a good option for patients with GERD, especially when extra-esophageal and night-time symptoms are present.
