Prognostic Significance of Volume-Based PET Parameters in Cancer Patients.
- Author:
Seung Hwan MOON
1
;
Seung Hyup HYUN
;
Joon Young CHOI
Author Information
- Publication Type:Research Support, Non-U.S. Gov't ; Review
- Keywords: Positron emission tomography; 18F-fluorodeoxyglucose; Metabolic tumor volume; Total lesion glycolysis; Prognosisrinogenesis
- MeSH: Fluorodeoxyglucose F18/diagnostic use; Glycolysis; Humans; Neoplasm Staging; Neoplasms/pathology/*radionuclide imaging; *Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Radiopharmaceuticals/diagnostic use; Tumor Burden
- From:Korean Journal of Radiology 2013;14(1):1-12
- CountryRepublic of Korea
- Language:English
- Abstract: Accurate prediction of cancer prognosis before the start of treatment is important since these predictions often affect the choice of treatment. Prognosis is usually based on anatomical staging and other clinical factors. However, the conventional system is not sufficient to accurately and reliably determine prognosis. Metabolic parameters measured by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) have the potential to provide valuable information regarding prognosis and treatment response evaluation in cancer patients. Among these parameters, volume-based PET parameters such as metabolic tumor volume and total lesion glycolysis are especially promising. However, the measurement of these parameters is significantly affected by the imaging methodology and specific image characteristics, and a standard method for these parameters has not been established. This review introduces volume-based PET parameters as potential prognostic indicators, and highlights methodological considerations for measurement, potential implications, and prospects for further studies.
