Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp..
10.20307/nps.2015.21.4.227
- Author:
Yan Lai JIA
1
;
Fei Fei GUAN
;
Jie MA
;
Chang Yun WANG
;
Chang Lun SHAO
Author Information
1. Key Laboratory of Marine Drugs, The ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China. shaochanglun@163.com
- Publication Type:In Vitro ; Original Article
- Keywords:
Marine Fungus;
Pestalotiopsis sp.;
Structure-Activity Relationship;
Antiviral Activity
- MeSH:
Fermentation;
Fungi*;
Inhibitory Concentration 50;
Ribavirin;
Structure-Activity Relationship;
Uridine
- From:Natural Product Sciences
2015;21(4):227-230
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3 and 4), along with 5'-O-acetyl uridine (5) first isolated as a natural product. The structure of the new compound (1) was established by comprehensive spectroscopic analysis and chemical methods. Compounds 1 - 4 possessed varying degrees of antiviral activities, which was reported for the first time. Compared to the positive control ribavirin (IC50 = 418.0 microM), pestalotiolide A (1) exhibited significant anti-EV71 activity in vitro, with an IC50 value of 27.7 microM. Furthermore, the preliminary structure-activity relationship of antiviral activities was also discussed.
