Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078.
10.20307/nps.2015.21.4.231
- Author:
Seung Min KIM
1
;
Sangkeun SON
;
Jong Won KIM
;
Eun Soo JEON
;
Sung Kyun KO
;
In Ja RYOO
;
Kee Sun SHIN
;
Hiroshi HIROTA
;
Shunji TAKAHASHI
;
Hiroyuki OSADA
;
Jae Hyuk JANG
;
Jong Seog AHN
Author Information
1. Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Korea. jsahn@kribb.re.kr, jangjh@kribb.re.kr
- Publication Type:Original Article
- Keywords:
azaphilone derivatives;
1,3-Dioxolane;
Marine-derived fungus;
Penicillium
- MeSH:
Chromatography;
Chromatography, High Pressure Liquid;
Fungi;
Penicillium*;
Silica Gel
- From:Natural Product Sciences
2015;21(4):231-236
- CountryRepublic of Korea
- Language:English
-
Abstract:
Two new azaphilone derivatives containing 1,3-dioxolane moiety, penidioxolanes A (1) and B (2), were isolated from marine-derived fungus Penicillium sp. KCB12C078, together with four known compounds (3-6) by chemical investigation. Compounds 1 - 6 were isolated by combination of silica gel, ODS column chromatography and preparative HPLC. Their structures were determined by analysis of spectroscopic data including 1D-, 2D-NMR, and MS techniques. The isolates were evaluated against cancer cell growth inhibition effects and antimicrobial activity.
