Effect of Imaging Time in the Magnetic Resonance Detection of Intracerebral Metastases Using Single Dose Gadobutrol.
10.3348/kjr.2014.15.1.145
- Author:
Ji Young JEON
1
;
Jin Woo CHOI
;
Hong Gee ROH
;
Won Jin MOON
Author Information
1. Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-914, Korea. mdmoonwj@naver.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Intracerebral metastases;
Single dose gadobutrol;
Gadovist;
MRI;
Contrast agent
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Brain Neoplasms/*diagnosis/*secondary;
Contrast Media/administration & dosage/*diagnostic use;
Female;
Humans;
Image Enhancement/methods;
Magnetic Resonance Imaging/*methods;
Male;
Middle Aged;
Observer Variation;
Organometallic Compounds/administration & dosage/*diagnostic use;
Time Factors
- From:Korean Journal of Radiology
2014;15(1):145-150
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To compare the effect of imaging time delay on the MR detection of intracerebral metastases using single dose gadobutrol. MATERIALS AND METHODS: Twenty-one patients with intracerebral metastases underwent contrast-enhanced MR with three-dimensional T1-weighted sequence at 1 minute, 5 minutes and 10 minutes after a single dose injection of gadobutrol. One hundred index metastatic lesions (1 to 30 mm; median, 7 mm) were chosen for the analysis. For the qualitative analysis, lesion conspicuity were assessed on a 1 (worst) to 5 (best) scale of the index lesions by an expert reader. For the quantitative analysis, signal intensity (SI) of enhancing lesions and normal parenchyma was measured to determine the contrast rate (CR, %) ([postcontrast SI lesion - postcontrast SI white matter] x 100 / postcontrast SI white matter) and the enhancement rate (ER, %) ([postcontrast SI lesion - baseline SI gray matter] x 100 / baseline SI gray matter). Statistical comparisons were made between three different time delays. RESULTS: Lesion conspicuity did not differ significantly among the three time delays (p = 0.097). Although the SI, CR and ER of lesions did not reveal any significant difference between 1 minute and 5 minutes delayed images, both the 1 minute and 5 minutes delayed images showed significantly higher CRs of lesions compared with the 10 minutes delayed images (p = 0.004 and p = 0.001, respectively). CONCLUSION: With single dose gadobutrol, imaging time delay did not have an effect on lesion conspicuity. Both 1-minute and 5-minute-delayed imaging after gadobutrol injection appears to be effective for the detection of intracerebral metastases.
