A Case of Ofloxacin-induced Torsades de Pointes and Abnormal ECG Change Mimicking Acute Myocardial Infarction.
10.4070/kcj.2002.32.9.815
- Author:
Jung Ho KIM
1
;
Gi Byoung NAM
;
Jae Min LIM
;
Jin Won HUH
;
Sun Young KIM
;
Kyoung Suk RHEE
;
Kee Joon CHOI
;
You Ho KIM
Author Information
1. Department of Internal Medicine, Ulsan University College of Medicine, Asan Medical Center, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Ofloxacin;
Torsades de pointes;
Myocardial infarction
- MeSH:
Aged;
Anti-Bacterial Agents;
Electrocardiography*;
Humans;
Myocardial Infarction*;
Ofloxacin;
Recurrence;
Syncope;
Torsades de Pointes*;
Tuberculosis, Pulmonary
- From:Korean Circulation Journal
2002;32(9):815-819
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
While some fluoroquinolone antibiotics can cause QT prolongation and Torsades de Pointes (TdP), serious proarrhythmic effects from ofloxacin have not been reported. Here, we report a case of ofloxacin-induced Torsades de Pointes with abnormal ECG changes, mimicking acute myocardial infarction. A 68-year-old man developed syncope following hospital admission for the treatment of pulmonary tuberculosis. TdP and marked QT prolongation (QT=0.44 sec, QTc=0.62 sec) were noted, with no remarkable serum electrolyte abnormality. The QT prolongation was followed by ST segment elevation, mimicking acute myocardial infarction. After discontinuation of ofloxacin, the QT interval shortened to 0.336 sec (QTc=0.481 sec), with no recurrence of TdP, although the QT interval remained mildly elevated during the hospital course. From this case, we propose that care should be taken in the use of ofloxacin, especially in patients susceptible to TdP.
