Fever.
10.3345/kjp.2007.50.2.121
- Author:
Taek Jin LEE
1
;
Dong Soo KIM
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea. dskim6634@yumc.yonsei.ac.kr
- Publication Type:Review
- Keywords:
Fever
- MeSH:
Acute-Phase Reaction;
Cytokines;
Fever*;
Inflammation;
Phagocytes
- From:Korean Journal of Pediatrics
2007;50(2):121-126
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fever has been recognized as a cardinal feature of disease since antiquity, but only recently has the pathophysiology of fever come to be understood. It became clear that the ultimate cause of fever is not a bacterial product (a so-called exogenous pyrogen) but a product of host inflammatory cells (i.e., an endogenous pyrogen). Many studies have demonstrated that mononuclear phagocytes are the principal source of endogenous pyrogen and that a variety of mononuclear cell products can mediate the febrile response. Cytokines are also important as mediators of the acute-phase response to infection and inflammation.
