Maximum standardized uptake value on positron emission tomography/computed tomography predicts clinical outcome in patients with relapsed or refractory diffuse large B-cell lymphoma.
- Author:
Hee Ryeong JANG
1
;
Moo Kon SONG
;
Joo Seop CHUNG
;
Deok Hwan YANG
;
Jeong Ok LEE
;
Junshik HONG
;
Su Hee CHO
;
Seong Jang KIM
;
Dong Hoon SHIN
;
Young Joo PARK
;
Jin Suk KANG
;
Jeong Eun LEE
;
Moon Won LEE
;
Ho Jin SHIN
Author Information
- Publication Type:Original Article
- Keywords: Positron emission tomography; SUVmax; aa-IPI
- MeSH: Carboplatin; Disease-Free Survival; Electrons*; Etoposide; Humans; Ifosfamide; Lymphoma, B-Cell*; Multivariate Analysis; Positron-Emission Tomography; Positron-Emission Tomography and Computed Tomography; Recurrence; Salvage Therapy
- From:Blood Research 2015;50(2):97-102
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Few clinical studies have clarified the prognostic factors that affect clinical outcomes for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after immunochemotherapy. METHODS: A total of 158 patients with relapsed or refractory DLBCL were enrolled. All patients underwent positron emission tomography/computed tomography (PET/CT) before and after salvage therapy. All enrolled patients previously received the ifosfamide, carboplatin, and etoposide regimen. Clinical outcomes were compared according to several factors (age > or = 65 years, low age-adjusted International Prognostic Index [aa-IPI], maximum standardized uptake value [SUVmax] <6.0 on PET/CT, time to relapse > or =12 months, complete response after salvage therapy). A low aa-IPI, SUVmax <6.0, and time to relapse > or = 12 months were independent prognostic factors for survival. RESULTS: In univariate analysis and multivariate analysis, SUVmax below 6.0 (P<0.001 for progression-free survival (PFS), P<0.001 for overall survival (OS)) and low aa-IPI (P<0.001 for PFS, P<0.001 for OS) were independent prognostic factors associated with favorable outcome. CONCLUSION: The aa-IPI and initial SUVmax were powerful prognostic factors in patients with relapsed or refractory DLBCL.
