Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases.
- Author:
Mimi KIM
1
;
Milim KIM
;
Yul Ri CHUNG
;
So Yeon PARK
Author Information
- Publication Type:Case Report
- Keywords: Microglandular adenosis; Breast; Carcinoma
- MeSH: Acinar Cells; Breast; Carcinoma, Intraductal, Noninfiltrating; Fibrocystic Breast Disease*; Follow-Up Studies; Humans; Recurrence; S100 Proteins; Triple Negative Breast Neoplasms
- From:Journal of Pathology and Translational Medicine 2017;51(4):422-427
- CountryRepublic of Korea
- Language:English
- Abstract: Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.
