Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal.
- Author:
Adam FABISIAK
1
;
Jakub WŁODARCZYK
;
Natalia FABISIAK
;
Martin STORR
;
Jakub FICHNA
Author Information
- Publication Type:Review
- Keywords: Ebastine; Irritable bowel syndrome; Mast cells; Receptors; histamine
- MeSH: Gastrointestinal Diseases; Histamine*; Irritable Bowel Syndrome*; Mast Cells; Receptors, Histamine*
- From:Journal of Neurogastroenterology and Motility 2017;23(3):341-348
- CountryRepublic of Korea
- Language:English
- Abstract: Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.
