Animal models for dengue vaccine development and testing.
10.7774/cevr.2017.6.2.104
- Author:
Woonsung NA
1
;
Minjoo YEOM
;
Il Kyu CHOI
;
Heejun YOOK
;
Daesub SONG
Author Information
1. College of Pharmacy, Korea University, Sejong, Korea. sds1@korea.ac.kr
- Publication Type:Review
- Keywords:
Dengue virus;
Vaccines;
Animal models
- MeSH:
Animals*;
Climate Change;
Dengue Virus;
Dengue*;
Endemic Diseases;
Humans;
Korea;
Mice;
Models, Animal*;
Vaccines
- From:Clinical and Experimental Vaccine Research
2017;6(2):104-110
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dengue fever is a tropical endemic disease; however, because of climate change, it may become a problem in South Korea in the near future. Research on vaccines for dengue fever and outbreak preparedness are currently insufficient. In addition, because there are no appropriate animal models, controversial results from vaccine efficacy assessments and clinical trials have been reported. Therefore, to study the mechanism of dengue fever and test the immunogenicity of vaccines, an appropriate animal model is urgently needed. In addition to mouse models, more suitable models using animals that can be humanized will need to be constructed. In this report, we look at the current status of model animal construction and discuss which models require further development.
