Epigenetic Mechanisms of Early Adverse Experience in the Development of Depression.
- Author:
Mi Kyoung SEO
1
;
Jung Goo LEE
;
Sung Woo PARK
;
Bong Ju LEE
;
Jun Hyung BAEK
;
Young Hoon KIM
Author Information
1. Paik Institute for Clinical Research, Inje University, Busan, Korea. neuro109@hanmail.net
- Publication Type:Review
- Keywords:
Depression;
Early life stress;
Pathophysiology;
Epigenetic
- MeSH:
Depression*;
DNA Methylation;
Epigenomics*;
Gene Expression;
Histones;
Prevalence;
Risk Factors;
Stress, Psychological
- From:Korean Journal of Psychopharmacology
2014;25(3):91-100
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Depression is a common mental illness with a high lifetime prevalence rate in the general population. However, the pathophysiology of depression is still poorly understood. Recent studies showed that environmental factors can affect gene expression by modifying epigenetic factors. Early life stress (ELS) is likely a risk factor of lifetime vulnerability to stress and development of depression. ELS or stressful lifetime can induce changes in gene expression through epigenetic mechanism, such as DNA methylation or histone modification. In this article, recent researches on the epigenetic mechanisms of depression will be discussed.
