Application of aptamers for assessment of vaccine efficacy.
10.7774/cevr.2017.6.2.160
- Author:
Soo Young YOON
1
;
Grace GEE
;
Kee Jong HONG
;
Sang Hwan SEO
Author Information
1. INTERPARK Bio-Convergence Center, Seoul, Korea. sanghwan.seo@imarketkorea.com
- Publication Type:Brief Communication
- Keywords:
Aptamers;
Vaccines;
Enzyme-linked immunosorbent assay;
Antigens;
Antibodies
- MeSH:
Antibodies;
Enzyme-Linked Immunosorbent Assay;
Vaccination;
Vaccines
- From:Clinical and Experimental Vaccine Research
2017;6(2):160-163
- CountryRepublic of Korea
- Language:English
-
Abstract:
Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy.
