15-Deoxy-Delta(12,14)-Prostaglandin J2 and Proinflammatory Cytokines in IgA Nephropathy.
- Author:
You Seok JEONG
1
;
Sang Heon SONG
;
Dong Won LEE
;
Soo Bong LEE
;
Byeong Yun YANG
;
Ihm Soo KWAK
Author Information
1. Department of Internal Medicine, Pusan National University, School of Medicine, Korea. iskwak@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Immunoglobulin A nephropathy;
15-deoxy-delta (12,14)-prostaglandin J2;
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
- MeSH:
Cohort Studies;
Corneal Dystrophies, Hereditary;
Cytokines;
Follow-Up Studies;
Glomerulonephritis, IGA;
Hematuria;
Humans;
Immunoglobulin A;
Inflammation;
Interleukin-23;
Interleukin-6;
Kidney;
Prostaglandin D2;
Proteinuria;
Transforming Growth Factor beta1
- From:Korean Journal of Nephrology
2008;27(3):307-318
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was performed to demonstrate a correlation among urinary 15d-PGJ2, proinflammatory cytokines (i.e. IL-23, IL-6, and TGF-beta1), and CRP, and to determinate the contributors to prognostic score and proteinuria in IgAN patients. METHODS: Fifty-four patients with biopsy-proven IgAN were enrolled. For comparison with IgAN, five MCD patients were also enrolled. Immunohistochemical staining for PPAR-gamma in kidney tissue and measurements of urinary IL-6, IL-23, TGF-beta1, 15d-PGJ2 and serum CRP were performed RESULTS: There was no difference according to PPAR-gamma staining. 15d-PGJ2 was negatively correlated with urinary IL-23, TGF-beta1, and CRP. Among proinflammatory cytokines and CRP, there were positive relationships with each other except for IL-23 and CRP. TGF-beta1 in the group having proteinuria more than 3 g/day was statistically higher than that in the sole hematuria group. However, in multivariate regression analysis, not a single relation was found between TGF-beta1 and proteinuria. Prognostic score was correlated with IL-6, IL-23, TGF-beta1, CRP, 15d-PGJ2, and 24hr proteinuria. 24hr proteinuria was correlated with IL-6 and 15d-PGJ2. In multivariate regression analysis, CRP, 15d-PGJ2, and 24hr proteinuria contributed to prognostic score, and only 15d-PGJ2 contributed to 24hr proteinuria. Last, urinary 15d-PGJ2 in IgAN was higher than that in MCD. CONCLUSION: Endogenous 15d-PGJ2 was associated with inflammation and might be considered as a material which could delay the damage of kidney in IgAN. In the future, larger cohort and long-term follow-up studies are needed to demonstrate the role of 15d-PGJ2 as prognostic indicator or marker of kidney damage.
