The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease.
10.3346/jkms.2015.30.10.1459
- Author:
Tae Rim SHIN
1
;
Yeon Mok OH
;
Joo Hun PARK
;
Keu Sung LEE
;
Sunghee OH
;
Dae Ryoung KANG
;
Seungsoo SHEEN
;
Joon Beom SEO
;
Kwang Ha YOO
;
Ji Hyun LEE
;
Tae Hyung KIM
;
Seong Yong LIM
;
Ho Il YOON
;
Chin Kook RHEE
;
Kang Hyeon CHOE
;
Jae Seung LEE
;
Sang Do LEE
Author Information
1. Division of Pulmonology, Allergy & Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Seoul, Korea.
- Publication Type:Original Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
- Keywords:
COPD;
Hyperinflation;
Survival;
Residual Volume;
Total Lung Capacity
- MeSH:
Aged;
Dyspnea/diagnosis/physiopathology;
Exercise Test;
Exercise Tolerance;
Female;
Forced Expiratory Flow Rates/physiology;
Forced Expiratory Volume;
Humans;
Lung/*physiopathology;
Male;
Middle Aged;
Prognosis;
Pulmonary Disease, Chronic Obstructive/*diagnosis/mortality/physiopathology;
Pulmonary Emphysema/*diagnosis/mortality/physiopathology;
Republic of Korea;
Residual Volume/*physiology;
Respiratory Function Tests;
Surveys and Questionnaires;
Total Lung Capacity/*physiology;
Vital Capacity;
Walking/physiology
- From:Journal of Korean Medical Science
2015;30(10):1459-1465
- CountryRepublic of Korea
- Language:English
-
Abstract:
The prognostic role of resting pulmonary hyperinflation as measured by residual volume (RV)/total lung capacity (TLC) in chronic obstructive pulmonary disease (COPD) remains poorly understood. Therefore, this study aimed to identify the factors related to resting pulmonary hyperinflation in COPD and to determine whether resting pulmonary hyperinflation is a prognostic factor in COPD. In total, 353 patients with COPD in the Korean Obstructive Lung Disease cohort recruited from 16 hospitals were enrolled. Resting pulmonary hyperinflation was defined as RV/TLC > or = 40%. Multivariate logistic regression analysis demonstrated that older age (P = 0.001), lower forced expiratory volume in 1 second (FEV1) (P < 0.001), higher St. George Respiratory Questionnaire (SGRQ) score (P = 0.019), and higher emphysema index (P = 0.010) were associated independently with resting hyperinflation. Multivariate Cox regression model that included age, gender, dyspnea scale, SGRQ, RV/TLC, and 6-min walking distance revealed that an older age (HR = 1.07, P = 0.027), a higher RV/TLC (HR = 1.04, P = 0.025), and a shorter 6-min walking distance (HR = 0.99, P < 0.001) were independent predictors of all-cause mortality. Our data showed that older age, higher emphysema index, higher SGRQ score, and lower FEV1 were associated independently with resting pulmonary hyperinflation in COPD. RV/TLC is an independent risk factor for all-cause mortality in COPD.
