Synthesis and antibacterial, antifungal effects of 5-bromo-1-morpholinomethyl isatin and derivatives
- Author:
Hung Viet Tran
- Publication Type:Journal Article
- Keywords:
morpholinomethyl isatin
- MeSH:
Anti-Bacterial Agents;
Isatin;
Antifungal Agents
- From:Pharmaceutical Journal
1999;282(10):10-12
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
By bromation of isatin, 5-bromoisatin (I) was obtained. Compound (I) underwent Mannich reaction and gave II with formaldehyde (36% aqueous solution) and morpholine. On treatment with the appropriate arylhydrazines, compound II gave 3-arylhydrazino-5-bromo-1-morpholinomethyl isatin (III-VIII). All synthesized compounds have been characterized by their IR, elemental analysis (II was characterized by MS, 1H.NMR). All synthesized compounds (I-VIII) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I, II showed an antibacterial activity on 8 strains of bacteria
