Correlation between Metabolic Syndrome and Cognition in the Elderly.
- Author:
Chang Hyung HONG
1
;
Eun A KIM
;
Hae Kwan CHEONG
;
Dong Woo LEE
;
Kyung Ryeol CHA
;
Kang Soo LEE
;
Byoung Hoon OH
Author Information
1. Department of Psychiatry, College of Medicine, Yonsei University, Seoul, Korea. drobh@chollian.net
- Publication Type:Original Article
- Keywords:
Metabolic syndrome;
Cognition;
K-MMSE;
Elderly;
ApoE genotype;
HDL cholesterol
- MeSH:
Adenosine Triphosphate;
Adult;
Aged*;
Alleles;
Apolipoproteins E;
Cholesterol;
Cholesterol, HDL;
Cognition*;
Dementia;
Education;
Genotype;
Gwangju;
Humans;
Logistic Models;
Male;
Surveys and Questionnaires;
Smoke;
Smoking;
Stroke
- From:Journal of Korean Neuropsychiatric Association
2006;45(4):349-356
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The purpose of this study is to find out the effect of ApoE genotype in correlation between metabolic syndrome and cognition of the elderly in the community. METHODS: A total of 1,305 subjects (440 men and 865 women) aged 60-98 years were analyzed from preliminary data of Gwangju Dementia and MCI Study (GDEMCIS). The metabolic syndrome was assessed as defined by the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, family history of dementia and stroke, and Korean version-Mini Mental State Examination (K-MMSE). We also examined ApoE genotype and analyzed associated factors with metabolic syndrome. RESULTS: These Metabolic syndrome was present in 28.6% of the subjects (13.4% of men and 36.3% of women). On multiple logistic regression analysis, low serum HDL cholesterol was associated with an increased risk for cognitive impairment (K-MMSE score < or = 17) adjusted by age, sex, educational level, and smoking in the presence of ApoE epsilon4 allele (OR 0.95, 95% CI 0.92-0.99). CONCLUSION: These results suggest that serum HDL cholesterol may affect cognitive function in the elderly in the presence of ApoE epsilon4 allele.
