Sarcoidosis Presenting with Massive Pleural Effusion and Elevated Serum and Pleural Fluid Carbohydrate Antigen-125 Levels.
10.4046/trd.2012.73.6.320
- Author:
In Seon LEE
1
;
Sae Byul KIM
;
Chan Soo MOON
;
Sung Mo JUNG
;
Song Yee KIM
;
Eun Young KIM
;
Ji Ye JUNG
;
Young Ae KANG
;
Young Sam KIM
;
Se Kyu KIM
;
Joon CHANG
;
Moo Suk PARK
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea. pms70@yuhs.ac
- Publication Type:Case Report
- Keywords:
Sarcoidosis;
Pleural Effusion;
CA-125 Antigen
- MeSH:
Adenosine Deaminase;
Biopsy;
CA-125 Antigen;
Exudates and Transudates;
Female;
Granuloma;
Humans;
Lymph Nodes;
Pleural Effusion;
Positron-Emission Tomography;
Prednisolone;
Sarcoidosis;
Thorax
- From:Tuberculosis and Respiratory Diseases
2012;73(6):320-324
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized.
