The effects of bone regeneration in rabbit calvarial defect with particulated and block type of hydroxyapatite.
10.5051/jkape.2009.39.3.321
- Author:
Sun Ja GU
1
;
Joo Yeon SOHN
;
Hyun Chang LIM
;
Yoo Jung UM
;
Ui Won JUNG
;
Chang Sung KIM
;
Yong Keun LEE
;
Seong Ho CHOI
Author Information
1. Department of Periodontology, Research institute of periodontal regeneration, College of Dentistry, Yonsei University, Seoul, Korea. shchoi726@yuhs.ac
- Publication Type:Original Article
- Keywords:
bone regeneration;
bone substitutes;
hydroxyapatites
- MeSH:
Bone Density;
Bone Regeneration;
Bone Substitutes;
Durapatite;
Humans;
Hydroxyapatites;
Male;
Minerals;
New Zealand;
Osteogenesis;
Rabbits;
Salicylamides;
Transplants;
Young Adult
- From:The Journal of the Korean Academy of Periodontology
2009;39(3):321-329
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to evaluate the bone regeneration of particulated hydroxyapatite(HA) and block type of hydroxyapatite graft in rabbit calvarial defects. METHODS: An 8 mm calvarial circular defects were created in sixteen young adult New Zealand white male rabbits (weight 3.0~3.5 kg). Each defects were filled with Bio-Oss, particulated HA and block type HA. Sham surgery control defects were filled with blood clots. The pecimens were harvested at 4 weeks and 8 weeks for histologic and histomorphometric evaluation. RESULTS: Histomorphometric analysis demonstrated statistical differences in defect closure, new bone formation, and bone density of the four groups. Block type of HA group showed increased bone formation and bone density at 4 weeks and 8 weeks compared with Bio-Oss group or sham surgery control group(p<0.05). CONCLUSIONS: Block type of HA is an effective material for osteoconduction in rabbit calvarial defects, which may acts as a guide in use of these products in human application.
