Cellular Density Evaluation for Malignant Lymphoma Using Equivalent Cross-Relaxation Rate Imaging - Initial Experience.
10.3348/kjr.2010.11.3.327
- Author:
Hideyuki NISHIOFUKU
1
;
Shigeru MATSUSHIMA
;
Yoshitaka INABA
;
Hidekazu YAMAURA
;
Yozo SATO
;
Yasuo MORISHIMA
;
Kimihiko KICHIKAWA
Author Information
1. Department of Radiology, Nara Medical University, Nara 634-8521, Japan. nishiofukuhideyuki@yahoo.co.jp
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Equivalent cross-relaxation rate imaging;
Cellular imaging;
Malignant lymphoma;
Molecular imaging
- MeSH:
Adult;
Aged;
Cell Count;
Diffusion Magnetic Resonance Imaging/*methods;
Female;
Humans;
Imaging, Three-Dimensional/methods;
Lymphoma, Follicular/*pathology;
Lymphoma, Large B-Cell, Diffuse/*pathology;
Male;
Middle Aged;
Observer Variation;
Retrospective Studies
- From:Korean Journal of Radiology
2010;11(3):327-332
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Equivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML). MATERIALS AND METHODS: Institutional Review Board approval was obtained and all patients provided informed consent. The study subjects included 15 patients with untreated ML who were histologically diagnosed with follicular lymphoma (FL; n = 8) or diffuse large B-cell lymphoma (DLBCL; n = 7). All patients underwent ECR imaging and the offset frequency was set at 7 ppm. RESULTS: The median ECR values were 71% (range; 60.7 to 75.5) in FL and 54% (50.8 to 59.4) in DLBCL (p = 0.001). The median cellular density was 1.5 +/- 0.17 x 10(6) / mm2 in FL and 1.0 +/- 0.70 x 10(6) / mm2 in DLBCL (p = 0.001). The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001). In FL and DLBCL, assuming ECR value cut-off points of 60%, both sensitivity and specificity were 100%. CONCLUSION: A strong correlation between ECR and cellular density in ML is demonstrated and the ECR may be a useful technique to differentiate between FL and DLBCL.
