Posttransplant Lymphoproliferative Disorders in Kidney Transplant Patients: Report from a Single-center over 25 Years.
- Author:
Jung Jun LEE
1
;
Dong Jin JOO
;
Soo Jin KIM
;
Kyu Ha HUH
;
Man Ki JU
;
Myoung Soo KIM
;
Soon Il KIM
;
Yu Seun KIM
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. yukim@yuhs.ac
- Publication Type:Original Article
- Keywords:
Posttransplant lymphoproliferative disease (PTLD);
Posttransplant malignancy;
Lymphoma
- MeSH:
Follow-Up Studies;
Gastrointestinal Tract;
Humans;
Kidney;
Liver;
Lung;
Lymphoma;
Lymphoproliferative Disorders;
Male;
Neck;
Organ Transplantation;
Prevalence;
Retrospective Studies;
Spleen;
Transplants
- From:The Journal of the Korean Society for Transplantation
2008;22(2):226-231
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Posttranplant lymphoproliferative disorder (PTLD) is a fatal complication of organ transplantation and standard treatment is either ineffective or too toxic to tolerate. This study aims to evaluate the characteristics of PTLD patients retrospectively. METHODS: We enrolled 2,630 kidney recipients who underwent transplantation from April 1979 to June 2007. And we retrospectively reviewed clinical manifestations of PTLD. RESULTS: Among one hundred ninety post-transplant malignancies from 2,630 renal recipients, 11 PTLD were diagnosed during 195.3+/-11.5 months (0~388 months) of mean follow up duration. PTLD predominantly occurred in male (Male : Female=10 : 1) and mean age of PTLD patients at the time of PTLD diagnosis was 51+/-15 year (18~71 year). Mean time interval to PTLD diagnosis were 126.6+/-74.8 months (6~240 months). In aspect of WHO classification, there were no early lesion, 1 polymorphic PTLD (9.1%), 10 monomorphic PTLD (90.9%) and no other types. In aspect of involved organ, GI tract was involved in 1 case, lung in 2 cases, bone in 2 cases, spleen in 2 cases, neck node in 2 cases, liver in 1 case, and multiple organs in 1 case. CONCLUSIONS: Our findings showed that the prevalence of PTLD was 0.46%, which was less than reports from Western countries. We also found that the late onset PTLD was more than early onset one, which was another difference from previous reports.
