A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery.
10.4093/dmj.2014.38.6.406
- Author:
Young Min CHO
1
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ymchomd@snu.ac.kr
- Publication Type:Review
- Keywords:
Bariatric surgery;
Diabetes mellitus, type 2;
Obesity;
Roux-en-Y gastric bypass;
Sleeve gastrectomy
- MeSH:
Bariatric Surgery*;
Bile;
Diabetes Mellitus, Type 2;
Gastrectomy;
Gastric Bypass;
Insulin Resistance;
Metabolism;
Microbiota;
Obesity;
Physiology
- From:Diabetes & Metabolism Journal
2014;38(6):406-415
- CountryRepublic of Korea
- Language:English
-
Abstract:
A cure for type 2 diabetes was once a mere dream but has now become a tangible and achievable goal with the unforeseen success of bariatric surgery in the treatment of both obesity and type 2 diabetes. Popular bariatric procedures such as Roux-en-Y gastric bypass and sleeve gastrectomy exhibit high rates of diabetes remission or marked improvement in glycemic control. However, the mechanism of diabetes remission following these procedures is still elusive and appears to be very complex and encompasses multiple anatomical and physiological changes. In this article, calorie restriction, improved beta-cell function, improved insulin sensitivity, and alterations in gut physiology, bile acid metabolism, and gut microbiota are reviewed as potential mechanisms of diabetes remission after Roux-en-Y gastric bypass and sleeve gastrectomy.
