Bone Mineral Density and Risk Factors in Recipients One Year after Renal Transplantation.
- Author:
Ki Hwan KWON
1
;
Kyung Ho PARK
;
Kyung Ock JEON
;
Hyun Jung KIM
;
Kyu Ha HUH
;
Myoung Soo KIM
;
Soon Il KIM
;
Yu Seun KIM
;
Kiil PARK
Author Information
1. Department of Transplant Surgery, Severance Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Bone mineral density;
Renal transplantation
- MeSH:
Absorptiometry, Photon;
Adult;
Bone Density*;
Dialysis;
Female;
Femur;
Humans;
Immunosuppression;
Kidney Transplantation*;
Male;
Risk Factors*;
Spine;
Transplants
- From:The Journal of the Korean Society for Transplantation
2003;17(1):43-50
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the change of bone mineral density (BMD) one year after renal transplantation, and examined the risk factors that affect the BMD by performing the dual energy X-ray absorptiometry in Korean adults renal transplants. METHODS: The results of pre-transplant and post-transplant BMD of 99 patients were analyzed in respect to sex, age, method and duration of dialysis before transplantation, immunosuppressive methods, history of previous graft and episode of acute rejection. Alfacalcidol or biphosphonate was not used postoperatively. Data were expressed as T-score and calculated percentage. Uni-variate analysis, T-test and ANOVA were used for the statistical analysis. P values less than 0.05 were considered significant. RESULTS: There were 66 male and 33 female patients. Change of T-score (and percentage) of lumbar vertebra and average of femur area in male were -0.353 (-2.3%) and -0.059 (-1.2%), respectively. Those of female patients were -0.483 (-5.2%) and 0.115 (-1.7%), respectively. The significant loss of BMD in the female lumbar spine was evident. Patients in 20's showed the largest loss of BMD [lumbar spine: -0.739 (-2.3%), femur: -0.206 (-3.1%), compared to other age groups. There were no significant differences by the mode and duration of dialysis, presence of diabetes, degree of HLA matching, history of previous graft, immunosuppression methods, and number of acute rejection episode. However we could accept the positive trend of BMD loss related to the kind of immunosuppression methods and number of acute rejection. CONCLUSION: There was significantly different loss of BMD after renal transplantation by the age and sex of the recipients. Although statistically not significant, kinds of immunosuppression and episode of acute rejection are likely to affect the BMD loss one year after renal transplantation.
