The immunogenicity and reactogenicity of Td booster vaccination in Korean preadolescents, aged with 11-12 years old.
10.3345/kjp.2008.51.11.1185
- Author:
Soo Young LEE
1
;
Ga Young KWAK
;
Hye Rin MOK
;
Jong Hyun KIM
;
Jae Kyun HUR
;
Kyung Il LEE
;
Joon Su PARK
;
Sang Hyuk MA
;
Hwang Min KIM
;
Jin Han KANG
Author Information
1. Department of Pediatrics, The Catholic University of Korea, Korea. kjhan@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Diphtheria-Tetanus vaccine;
Immunization;
Efficiency;
Safety
- MeSH:
Aged;
Antibodies;
Compliance;
Diphtheria;
Diphtheria-Tetanus Vaccine;
Diphtheria-Tetanus-acellular Pertussis Vaccines;
Enzyme-Linked Immunosorbent Assay;
Humans;
Immunization;
Immunization, Secondary;
Incidence;
Korea;
Tetanus;
Vaccination
- From:Korean Journal of Pediatrics
2008;51(11):1185-1190
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was undertaken to evaluate the immunogenicity and reactogenicity of Td booster immunization in early preadolescents of Korea. METHODS: Healthy preadolescents, who had been vaccinated with 4 or 5 doses of DTaP vaccines until 6 years old age, were enrolled in this study from August 2006 to April 2007 . Diphtheria and tetanus anti-toxoid antibodies in sera were measured by ELISA just before vaccination and 4 weeks after vaccination to evaluate immunogenicity. Local and systemic adverse reactions observed for 4 weeks after vaccination to access reactogenicity. RESULTS: 183 preadolescents were enrolled and mean age was 11.40+/-0.51 years old. All subjects achieved seroprotective diphtheria and tetanus anti-toxoid antibodies (titers > or =0.1 IU/mL) after Td booster vaccination. Among 183 vaccinees, 73.8% showed local adverse reactions and 37.2% systemic adverse reactions. Pain at injection site (66.1%) was the most common local reaction, and the most commonly shown systemic reaction was myalgia (17.5%). The adverse reactions were spontaneously relieved within three days after vaccination. CONCLUSION: Td vaccine in this study was high immunogenic and showed an acceptable tolerance in Korean preadolescents. Td booster vaccination at 11 -12 years old is the most effective method to increase compliance of the vaccination and to decrease the incidence of diphtheria and tetanus.
