Serum Retinol-Binding Protein-4 Levels Are Increased in HIV-Infected Subjects with Metabolic Syndrome Receiving Highly Active Antiretroviral Therapy.
10.3349/ymj.2012.53.6.1211
- Author:
Su Jin JEONG
1
;
Bum Sik CHIN
;
Yun Tae CHAE
;
Sung Joon JIN
;
Nam Su KU
;
Ji Hyeon BAEK
;
Sang Hoon HAN
;
Chang Oh KIM
;
Jun Yong CHOI
;
Young Goo SONG
;
Hyun Chul LEE
;
June Myung KIM
Author Information
1. Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea. shhan74@yuhs.ac
- Publication Type:Brief Communication
- Keywords:
Retinol-binding protein-4;
metabolic syndrome;
HIV;
highly active antiretroviral therapy
- MeSH:
Adult;
*Antiretroviral Therapy, Highly Active;
Enzyme-Linked Immunosorbent Assay;
Female;
HIV Infections/*blood/*drug therapy;
Humans;
Male;
Metabolic Syndrome X/*blood/*drug therapy;
Middle Aged;
Retinol-Binding Proteins, Plasma/*metabolism
- From:Yonsei Medical Journal
2012;53(6):1211-1215
- CountryRepublic of Korea
- Language:English
-
Abstract:
Metabolic syndrome is an important long term complication in chronic asymptomatic HIV-infected subjects under highly active antiretroviral therapy (HAART), because it can contribute to morbidity and mortality via cardiovascular disease (CVD). Therefore, a predictive marker for early detection of metabolic syndrome may be necessary to prevent CVD in HIV-infected subjects. Retinol-binding protein-4 (RBP-4) has been shown to be associated with metabolic syndrome in various non-HIV-infected populations. We performed a cross-sectional study to evaluate whether serum RBP-4 levels are correlated with metabolic syndrome in HIV-infected subjects receiving HAART. In total, 98 HIV-infected Koreans who had been receiving HAART for at least 6 months were prospectively enrolled. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III criteria, and serum RBP-4 concentrations were measured using human RBP-4 sandwich enzyme-linked immunosorbent assay. Serum RBP-4 levels were significantly higher in HIV-infected subjects receiving HAART with metabolic syndrome (n=33, 33.9+/-7.7 microg/mL) than in those without it (n=65, 29.9+/-7.2 microg/mL) (p=0.012). In multivariate linear regression analysis, the number of components of metabolic syndrome presented and waist circumference were independently, significantly correlated with RBP-4 (p=0.018 and 0.030, respectively). In conclusion, we revealed a strong correlation between RBP-4 and the number of components of metabolic syndrome in HIV-infected subjects receiving HAART.
