A Multicenter Study of Pertussis Infection in Adults with Coughing in Korea: PCR-Based Study.
10.4046/trd.2012.73.5.266
- Author:
Sunghoon PARK
1
;
Myung Gu LEE
;
Kwan Ho LEE
;
Yong Bum PARK
;
Kwang Ha YOO
;
Jeong Woong PARK
;
Changhwan KIM
;
Yong Chul LEE
;
Jae Seuk PARK
;
Yong Soo KWON
;
Ki Hyun SEO
;
Hui Jung KIM
;
Seung Min KWAK
;
Ju Ock KIM
;
Seong Yong LIM
;
Hwa Young SUNG
;
Sang Oun JUNG
;
Ki Suck JUNG
Author Information
1. Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. pulmoks@hallym.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Adult;
Cough;
Incidence;
Whooping Cough;
Signs and Symptoms
- MeSH:
Adult;
Age Distribution;
Centers for Disease Control and Prevention (U.S.);
Cough;
Dyspnea;
Humans;
Incidence;
Outpatients;
Polymerase Chain Reaction;
Sputum;
Whooping Cough
- From:Tuberculosis and Respiratory Diseases
2012;73(5):266-272
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Limited data on the incidence and clinical characteristics of adult pertussis infections are available in Korea. METHODS: Thirty-one hospitals and the Korean Centers for Disease Control and Prevention collaborated to investigate the incidence and clinical characteristics of pertussis infections among adults with a bothersome cough in non-outbreak, ordinary outpatient settings. Nasopharyngeal aspirates or nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and culture tests. RESULTS: The study enrolled 934 patients between September 2009 and April 2011. Five patients were diagnosed as confirmed cases, satisfying both clinical and laboratory criteria (five positive PCR and one concurrent positive culture). Among 607 patients with cough duration of at least 2 weeks, 504 satisfied the clinical criteria of the US Centers for Disease Control and Prevention (i.e., probable case). The clinical pertussis cases (i.e., both probable and confirmed cases) had a wide age distribution (45.7+/-15.5 years) and cough duration (median, 30 days; interquartile range, 18.0~50.0 days). In addition, sputum, rhinorrhea, and myalgia were less common and dyspnea was more common in the clinical cases, compared to the others (p=0.037, p=0.006, p=0.005, and p=0.030, respectively). CONCLUSION: The positive rate of pertussis infection may be low in non-outbreak, ordinary clinical settings if a PCR-based method is used. However, further prospective, well-designed, multicenter studies are needed.
