A Case of Combined Hepatocellular-Cholangiocarcinoma with Sarcomatous Transformation and Second Primary Colon Cancer.
- Author:
Jae Hi KIM
1
;
Yong Gu LEE
;
Jun LEE
;
Cheol Kweon JUNG
;
Hyeong Tae KIM
;
Haeyoun KANG
;
Kwang Hyun KHO
;
Sung Pyo HONG
;
Seong Gyu HWANG
;
Pil Won PARK
;
Gyu Sung RIM
Author Information
1. Department of Internal Medicine, College of Medicine, Pochon CHA University, Korea. sghwang@cha.ac.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Neoplasm/Liver/Combined hepatocellular-cholangiocarcinoma;
Colon neoplasms;
Second primary cancer
- MeSH:
Adenocarcinoma/*pathology;
Aged;
Bile Duct Neoplasms/*pathology;
*Bile Ducts, Intrahepatic;
Carcinoma, Hepatocellular/*pathology;
Cholangiocarcinoma/*pathology;
Colonic Neoplasms/*pathology;
English Abstract;
Humans;
Liver Neoplasms/*pathology;
Male;
Neoplasms, Second Primary/*pathology
- From:The Korean Journal of Hepatology
2004;10(2):142-147
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer, featuring both hepatocellular and biliary epithelial differentiations. An intrahepatic tumor may be considered as a metastatic lesion. It has been suggested in the literature that the likelihood of metastasis in the cirrhotic liver is lower than that in the non-cirrhotic liver. A rare case of combined hepatocellular-cholangiocarcinoma and second primary colon adenocarcinoma in a 67-year-old male patient with liver cirrhosis is presented. Histologically, the intrahepatic mass was composed of a spindle cell sarcomatous component; a hepatocellular carcinoma component; and a cholangiocarcinoma component. There were focal transitional regions among the different components. Immunohistochemically, the cholangiocarcinoma component of the intrahepatic mass showed positive reactions for CK-7 but negative reactions for CK-20. The adenocarcinoma of the colon showed positive reactions for CK-20 but negative reactions for CK-7.