Polyomavirus Renal Infection Confirmed by Electron Microscopy in a Patient with Acquired Immunodeficiency Syndrome: An Autopsy Case Report.
- Author:
Na Rae KIM
1
;
Byoung Kwon KIM
;
Je G CHI
Author Information
1. Department of Pathology, Seoul National University College of Medicine, Seoul 110-799, Korea. pathr@plaza.snu.ac.kr
- Publication Type:Case Report
- Keywords:
Polyomavirus;
HIV;
Kidney;
Electron Microscopy
- MeSH:
Acquired Immunodeficiency Syndrome*;
Adenoviridae;
Adolescent;
Adult;
Autopsy*;
Basophils;
BK Virus;
Brain;
Chromatin;
Cytomegalovirus Infections;
Epithelial Cells;
Gastrointestinal Tract;
Herpesvirus 4, Human;
HIV;
Humans;
Intranuclear Inclusion Bodies;
Kidney;
Lung;
Male;
Microscopy, Electron*;
Polyomavirus Infections;
Polyomavirus*;
Sarcoma, Kaposi;
Simplexvirus;
Virion
- From:Korean Journal of Pathology
2001;35(2):168-171
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Polyomavirus infection commonly occurs in childhood and adolescence, remaining in a latent status and reactivated in an immunocompromised status. We report herein an autopsy case of HIV-positive 41-year-old male, who succumbed to disseminated Kaposi sarcoma and cytomegalovirus infection involving the gastrointestinal tract, lung and brain. The involved kidney showed minimal inflammatory infiltrates and tubular injury: the nuclei of tubular epithelial cells were markedly enlarged with central clearing and peripheral chromatin margination or bore basophilic nuclear inclusions. Inclusion-bearing tubular epithelial cells were negative for the viral immunostains including herpes simplex virus, Epstein-Barr virus and adenovirus. Electron microscopy disclosed 42 nm intranuclear viral particles compatible with the BK polyomavirus. The viral particles were icosahedral in paracrystalline array and nonenveloped.
