Vitamin D Deficiency Is Highly Concomitant but Not Strong Risk Factor for Mortality in Patients Aged 50 Year and Older with Hip Fracture.
10.11005/jbm.2015.22.4.205
- Author:
Gyeong Hak LEE
1
;
Jung Won LIM
;
Yong Gum PARK
;
Yong Chan HA
Author Information
1. Department of Orthopaedic Surgery, National Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Hip fractures;
Mortality;
Risk factors;
Vitamin D
- MeSH:
Hip Fractures;
Hip*;
Humans;
Mortality*;
Multivariate Analysis;
Osteoporosis;
Prevalence;
Proportional Hazards Models;
Risk Factors*;
Vitamin D Deficiency*;
Vitamin D*;
Vitamins*
- From:Journal of Bone Metabolism
2015;22(4):205-209
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The purpose of this study was to ascertain the prevalence of vitamin D deficiency and risk factors associated with mortality in patients > or =50-year-of-age with hip fractures. METHODS: A total of 489 patients > or =50-year-of-age who sustained a hip fracture from January 2010 to October 2014 were followed-up for a minimum of 1 year. Clinical and radiological outcomes were evaluated including prevalence of vitamin D deficiency. Crude mortality rates were calculated, and the effects of different risk factors on mortality were assessed. RESULTS: Vitamin D deficiency was present in 76.5% of cases (n=237). The prevalence of vitamin D insufficiency was 12.3%, and only 11.2% of patients had normal vitamin D levels. Accumulated mortality was 11% (54 patients) at 1 year. A univariate analysis showed that vitamin D deficiency (P=0.012), age (P<0.001), BMI (P<0.001), type of management (P<0.001), American Society of Anesthesiologists (ASA) score (P=0.009), pre-fracture ambulatory status (P<0.001), and osteoporosis (P<0.001) were associated with mortality. A multivariate analysis performed using a Cox proportional hazards model demonstrated that ASA score (P=0.001) and pre-fracture ambulatory status (P=0.011) were independently associated with mortality after hip fracture. CONCLUSIONS: We did not find a relationship between serum 25-hydroxy-vitamin D levels and mortality after hip fracture, although we observed a high prevalence of vitamin D deficiency and a significant association with mortality in the univariate analysis.
