Beneficial effects of natural Jeju groundwaters on lipid metabolism in high-fat diet-induced hyperlipidemic rats.
- Author:
Yan Chao WANG
1
;
Jin Miao LU
;
Hui Zi JIN
;
Ai Niu MA
;
Jin Yang ZHANG
;
Nian GONG
;
Qi XIAO
;
Bin ZHU
;
Ying Fang LV
;
Na YU
;
Wei Dong ZHANG
;
Yong Xiang WANG
Author Information
- Publication Type:Original Article
- Keywords: Jeju groundwaters; fatty liver; hyperlipidemia; vanadium; ferrous ion autoxidation
- MeSH: Animals; Body Weight; Cholesterol; Drinking; Drinking Water; Fatty Liver; Groundwater*; Hyperlipidemias; Hypertrophy; Ions; Korea; Lipid Metabolism*; Lipoproteins; Liver; Minerals; Rats*; Simvastatin; Triglycerides; Vanadium; Water
- From:Nutrition Research and Practice 2014;8(2):165-171
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (Samdasoo(TM)), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, serum lipids and lipoproteins, and liver histopathology in high-fat diet-induced hyperlipidemic rats. MATERIALS/METHODS: Rats were randomly and equally divided into 6 groups. Different water samples were supplied to the hyperlipidemic rats as their daily drinking water and the widely-used anti-hyperlipidemic drug simvastatin was used as a positive control. Body weight, serum lipids and lipoproteins were measured weekly. Liver weight, liver index and liver histopathology were examined after the execution of the rats. RESULTS: After drinking Jeju groundwaters for two months, S2 but not S3 significantly reduced weight growth and serum triglycerides levels and increased high density lipoprotein-C (HDL-C) without affecting total cholesterol or LDL-C. S1 and particularly S2 significantly reduced the severity of liver hypertrophy and steatosis. All Groundwaters had much higher contents of vanadium (S3>S2>S1>>tap water) whereas S1 and S2 but not S3 markedly blocked autoxidation of ferrous ions. CONCLUSION: Jeju Groundwater S1 and particularly S2 exhibit protective effects against hyperlipidemia and fatty liver and hypothesize that the beneficial effect of Jeju Groundwaters may be contributed from blockade of autoxidation of ferrous ions rather than their high contents of vanadium.
