A Case of Primary Melanoma of the Anus that Spread to the Submucosa of the Rectum.
- Author:
Sung Whan CHO
1
;
Won Il PARK
;
Hyung Yook KIM
;
Kwang Jin KIM
;
Ung Suk YANG
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Bong Seng Memorial Hospital, Busan, Korea. sungwhanch@hanmail.net
- Publication Type:Case Report
- Keywords:
Anorectal malignant melanoma;
Submucosal metastasis
- MeSH:
Aged;
Anal Canal;
Brain;
Colorectal Neoplasms;
Female;
Hemorrhage;
Hemorrhoids;
Humans;
Light;
Melanocytes;
Melanoma;
Microscopy;
Neoplasm Metastasis;
Pigmentation;
Rectum;
S100 Proteins;
Ulcer
- From:Korean Journal of Gastrointestinal Endoscopy
2008;37(4):299-302
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary malignant melanoma of the anorectum is rare, representing about 1% of all colorectal carcinoma and less than 1% of all melanomas. The most common symptom of malignant melanoma of the anorectum is anal bleeding and this is often misdiagnosed as hemorrhoids. A 72-year-old female patient was admitted due to intermittent anal bleeding for 6 months. Colonoscopic examination showed a large exophytic mass with an irregularly ulcerated and greenish-brown pigmentation on the anus and the examination also simultaneously showed a submucosal tumor-like lesion in the rectum that was located 5 cm from the anal verge. Light microscopy of the tumor revealed malignant melanocytes and the tumor cells reacted positively for immunohistochemical staining with S-100 protein and HMB-45. Distant metastasis to the brain was detected on brain MRI.
