A Case of Familial Crohn's Disease Observed in a Parent and His Offspring.
- Author:
Hyun Seok CHO
1
;
Tae Jun BYUN
;
Sang Bong AHN
;
Tae Yeob KIM
;
Chang Soo EUN
;
Yong Cheol JEON
;
Yong Seok KIM
;
Dong Soo HAN
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Guri, Korea. hands@hanyang.ac.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Familial;
Crohn's disease
- MeSH:
Child;
Colonoscopy;
Crohn Disease/*diagnosis/etiology/radiography;
Family;
Genetic Predisposition to Disease;
Humans;
Male;
Middle Aged;
Pedigree
- From:The Korean Journal of Gastroenterology
2008;52(4):247-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Crohn's disease (CD), one of the major forms of idiopathic inflammatory bowel disease (IBD), is thought to be related to genetic susceptibility coupled with environmental factors. A positive family history is the strongest risk factor for the development of CD. The 10-fold increase in the familial risk of CD strongly suggests that these disorders have a genetic background. The prevalence of IBD in Asian populations is lower than in Western populations, which may be due to genetic influences, environmental factors, or a combination of both. In a Korean study, only 0.25% of parents had IBD in CD probands and all of them had ulcerative colitis. The term of familial CD was used only for those with one or more first-degree relatives with confirmed CD. There are few case reports about familial Crohn's disease in Korea. We report a case of familial CD that the father, the first degree relative was diagnosed as small bowel CD after confirming his son as having CD.
