Efficacy of Clozapine on Schizophrenia with Polydipsia: Two Cases Experience.
- Author:
Chul Eung KIM
1
;
Nam Jun PARK
;
Min Hee KANG
;
Jae Nam BAE
Author Information
1. Department of Psychiatry, College of Medicine, Inha University, Incheon, Korea.
- Publication Type:Case Report
- Keywords:
Polydipsia;
Hyponatremia;
Schizophrenia;
Clozapine
- MeSH:
Clozapine*;
Humans;
Hyponatremia;
Inpatients;
Polydipsia*;
Psychotic Disorders;
Schizophrenia*
- From:Korean Journal of Psychopharmacology
2003;14(1):63-66
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Polydipsia occurs frequently in chronic schizophrenic patients, some of whom develop hyponatremia. Although the underlying pathophysiology of polydipsia among psychiatric patients, recent reports indicate that clozapine treatment improves polydipsia-hyponatremia in schizophrenia. Two schizophrenic patients with polydipsia, followed for more than two years, showed improvement on clozapine. Case 1 was a patient without history of hyponatremia who improved from polydipsia and psychosis. Case 2 was an inpatient with polydipsia and hyponatremia who showed improvement of polydipsia and did nor recur hyponatremia. The limited information provided by these case reports suggest the need for controlled studies of the clozapine effect on schizophrenic patients with polydipsia.
