Role of Atypical Pathogens and the Antibiotic Prescription Pattern in Acute Bronchitis: A Multicenter Study in Korea.
10.3346/jkms.2015.30.10.1446
- Author:
Sunghoon PARK
1
;
Kil Chan OH
;
Ki Seong KIM
;
Kyu Tae SONG
;
Kwang Ha YOO
;
Yun Su SHIM
;
Young Ju LEE
;
Myung Goo LEE
;
Jang Uk YUN
;
Hyun Su KIM
;
Yee Hyung KIM
;
Won Jun LEE
;
Do Il KIM
;
Hyung Gun CHA
;
Jae Myung LEE
;
Jung San SEO
;
Ki Suck JUNG
Author Information
1. Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea. pulmoks@hallym.ac.kr
- Publication Type:Original Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
- Keywords:
Acute Bronchitis;
Antibiotics;
Atypical Pathogens;
Korea
- MeSH:
Anti-Bacterial Agents/therapeutic use;
Bordetella parapertussis/genetics/*isolation & purification;
Bordetella pertussis/genetics/*isolation & purification;
Bronchitis/drug therapy/*microbiology;
Chlamydophila pneumoniae/genetics/*isolation & purification;
Community-Acquired Infections/microbiology;
Female;
Humans;
Hypertension/complications;
Legionella pneumophila/genetics/*isolation & purification;
Male;
Middle Aged;
Mycoplasma pneumoniae/genetics/*isolation & purification;
Real-Time Polymerase Chain Reaction;
Republic of Korea;
Sputum/microbiology
- From:Journal of Korean Medical Science
2015;30(10):1446-1452
- CountryRepublic of Korea
- Language:English
-
Abstract:
The role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. This study was conducted at 22 hospitals (17 primary care clinics and 5 university hospitals) in Korea. Outpatients (aged > or = 18 yr) who had an acute illness with a new cough and sputum (< or = 30 days) were enrolled in 2013. Multiplex real-time polymerase chain reaction (RT-PCR) was used to detect five atypical bacteria. A total of 435 patients were diagnosed as having acute bronchitis (vs. probable pneumonia, n = 75), and 1.8% (n = 8) were positive for atypical pathogens (Bordetella pertussis, n = 3; B. parapertussis, n = 0; Mycoplasma pneumoniae, n = 1; Chlamydophila pneumoniae, n = 3; Legionella pneumophila, n = 1). Among clinical symptoms and signs, only post-tussive vomiting was more frequent in patients with atypical pathogens than those without (P = 0.024). In all, 72.2% of the enrolled patients received antibiotic treatment at their first visits, and beta-lactams (29.4%) and quinolones (20.5%) were the most commonly prescribed agents. In conclusion, our study demonstrates that the incidence of atypical pathogens is low in patients with acute bronchitis, and the rate of antibiotic prescriptions is high.
