Qualitative and Quantitative Analysis with Contrast-Enhanced Ultrasonography: Diagnosis Value in Hypoechoic Renal Angiomyolipoma.
10.3348/kjr.2015.16.2.334
- Author:
Qing LU
1
;
Bei Jian HUANG
;
Wen Ping WANG
;
Cui Xian LI
;
Li Yun XUE
Author Information
1. Shanghai Imaging Institute of Medicine, Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China. huang.beijian@zs-hospital.sh.cn
- Publication Type:Original Article
- Keywords:
Angiomyolipoma;
Renal cell carcinoma;
Contrast-enhanced ultrasonography;
Quantitative analysis;
Minimal fat
- MeSH:
Adult;
Aged;
Angiomyolipoma/*diagnosis/pathology/*ultrasonography;
Carcinoma, Renal Cell/*diagnosis/pathology/*ultrasonography;
Contrast Media;
Diagnosis, Differential;
Female;
Humans;
Kidney Neoplasms/diagnosis/pathology/*ultrasonography;
Language;
Lipoma/ultrasonography;
Male;
Middle Aged;
Sensitivity and Specificity
- From:Korean Journal of Radiology
2015;16(2):334-341
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the value of enhancement features and quantitative parameters of contrast-enhanced ultrasonography (CEUS) in differentiating solid hypoechoic renal angiomyolipomas (AMLs) from clear cell renal cell carcinomas (ccRCCs). MATERIALS AND METHODS: We analyzed the enhancement features and quantitative parameters of CEUS in 174 hypoechoic renal masses (32 AMLs and 142 ccRCCs) included in the study. RESULTS: Centripetal enhancement pattern was more common in AMLs than in ccRCCs on CEUS (71.9% vs. 23.2%, p < 0.001). At peak enhancement, all AMLs showed homogeneous enhancement (100% in AML, 27.5% in ccRCCs; p < 0.001). Quantitative analysis showed no significant difference between rise time and time to peak. Tumor-to-cortex (TOC) enhancement ratio in AMLs was significantly lower than that in ccRCCs (p < 0.001). The criteria of centripetal enhancement and homogeneous peak enhancement together with TOC ratio < 91.0% used to differentiate hypoechoic AMLs from ccRCCs resulted in a sensitivity and specificity of 68.9% and 95.8%, respectively. CONCLUSION: Both qualitative and quantitative analysis with CEUS are valuable in the differential diagnosis of hypoechoic renal AMLs from ccRCCs.
