Multiphase Contrast-Enhanced Magnetic Resonance Imaging Features of Bacillus Calmette-Guerin-Induced Granulomatous Prostatitis in Five Patients.
10.3348/kjr.2015.16.2.342
- Author:
Hiroshi KAWADA
1
;
Masayuki KANEMATSU
;
Satoshi GOSHIMA
;
Hiroshi KONDO
;
Haruo WATANABE
;
Yoshifumi NODA
;
Yukichi TANAHASHI
;
Nobuyuki KAWAI
;
Hiroaki HOSHI
Author Information
1. Department of Radiology, Gifu University Hospital, Gifu 501-1194, Japan. masa_gif@yahoo.co.jp
- Publication Type:Brief Communication
- Keywords:
Granulomatous prostatitis;
Multiphase contrast-enhanced MR imaging;
BCG;
Ring enhancement
- MeSH:
Aged;
Gadolinium/*diagnostic use;
Humans;
Image Enhancement;
Immunotherapy/*adverse effects;
Magnetic Resonance Imaging/*methods;
Magnetic Resonance Spectroscopy;
Male;
Middle Aged;
Mycobacterium bovis/*pathogenicity;
Prostate-Specific Antigen/blood;
Prostatic Neoplasms/diagnosis;
Prostatitis/*diagnosis;
Retrospective Studies;
Urinary Bladder Neoplasms/drug therapy
- From:Korean Journal of Radiology
2015;16(2):342-348
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the multiphase contrast-enhanced magnetic resonance (MR) imaging features of Bacillus Calmette-Guerin (BCG)-induced granulomatous prostatitis (GP). MATERIALS AND METHODS: Magnetic resonance images obtained from five patients with histopathologically proven BCG-induced GP were retrospectively analyzed for tumor location, size, signal intensity on T2-weighted images (T2WI) and diffusion-weighted images (DWI), apparent diffusion coefficient (ADC) value, and appearance on gadolinium-enhanced multiphase images. MR imaging findings were compared with histopathological findings. RESULTS: Bacillus Calmette-Guerin-induced GP (size range, 9-40 mm; mean, 21.2 mm) were identified in the peripheral zone in all patients. The T2WI showed lower signal intensity compared with the normal peripheral zone. The DWIs demonstrated high signal intensity and low ADC values (range, 0.44-0.68 x 10(-3) mm2/sec; mean, 0.56 x 10(-3) mm2/sec), which corresponded to GP. Gadolinium-enhanced multiphase MR imaging performed in five patients showed early and prolonged ring enhancement in all cases of GP. Granulomatous tissues with central caseation necrosis were identified histologically, which corresponded to ring enhancement and a central low intensity area on gadolinium-enhanced MR imaging. The findings on T2WI, DWI, and gadolinium-enhanced images became gradually obscured with time. CONCLUSION: Bacillus Calmette-Guerin-induced GP demonstrates early and prolonged ring enhancement on gadolinium-enhanced MR imaging which might be a key finding to differentiate it from prostate cancer.
