Surgical Treatment of Intractable Epilepsy with Benign Brain Lesion.
- Author:
Dae Hee SEO
1
;
Seung Chyul HONG
;
Seung Bong HONG
;
Dae Won SEO
Author Information
1. Department of Neurosurgery, Myongji Hospital, Kwandong University, Goyang, Korea.
- Publication Type:Review
- Keywords:
Intractable seizure;
Epilepsy surgery;
Dysembryoplastic neuroepithelial tumor;
Cavernous angioma;
Cortical dysplasia
- MeSH:
Brain*;
Cicatrix;
Diffusion;
Epilepsies, Partial;
Epilepsy*;
Hemangioma, Cavernous;
Hemosiderin;
Humans;
Malformations of Cortical Development;
Neurologic Manifestations;
Seizures
- From:Journal of Korean Epilepsy Society
2005;9(1):3-9
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Epilepsy surgery can be a safe, effective treatment for individuals with intractable partial epilepsy. There is increasing evidence that brain abnormalities in focal epilepsy are not restricted to a single area. The longstanding debate around the relationship between structural lesions and the epileptic zone remains unresolved. Patients with DNT (dysembryoplastic neuroepithelial tumor), which is an essentially benign tumor, can be cured by epilepsy surgery-oriented approach. Cortical dysplasia is frequently associated with DNT and seems to contribute to epileptogenic activity of DNT. Surgical treatment should be aimed at removal of the associated cortical dysplasia as well as DNT itself for ideal treatment of the disease. Simple lesionectomy of cavernous angioma would relieve seizures significantly, but not always. The concept of epilepsy surgery needs to be recruited in the treatment of cavernous angioma with seizures because diffusion of hemosiderin into the surrounding brain tissue and formation of cortical scars can make epileptogenic areas. Cortical dysplasia is a highly epileptogenic lesion constituting an important cause of medically intractable epilepsy and surgery is a treatment of choice in a selected group of patients. Identification and complete resection of the lesion and ictal onset zone are necessary to achieve a good surgical results. Intractable epilepsy accompanied by benign brain lesions can be treated surgically using the entire armamentarium of presurgical investigations. Deliberate resective procedures aimed at complete removal of dysplastic tissue and epiletogenically active areas on and around the lesion ensure excellent seizure control without permanent neurologic deficit.
