A comparison of the clinical duration and recovery characteristics of cisatracurium after priming using rocuronium or cisatracurium: preliminary study.
10.4097/kjae.2014.66.1.18
- Author:
Ki Tae JUNG
1
;
Jae Wook KIM
;
Tong Kyu KIM
;
Tae Hun AN
Author Information
1. Department of Anesthesiology and Pain Medicine, School of Medicine, Chosun University, Gwangju, Korea. than@chosun.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Cisatracurium;
Neuromuscular monitoring;
Recovery of function;
Rocuronium
- MeSH:
Anesthesia;
Humans;
Intubation;
Neuromuscular Monitoring;
Propofol;
Recovery of Function
- From:Korean Journal of Anesthesiology
2014;66(1):18-22
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The priming technique can speed up the onset of cisatracurium during intubation. However, there have been no reports on the effect of the priming technique on duration or recovery profile of cisatracurium. Therefore, we attempted to determine whether or not a priming technique with rocuronium or cisatracurium can affect clinical duration or recovery profiles of cisatracurium. METHODS: A total of 36 patients, ASA I and II, who were scheduled to undergo elective surgery, were enrolled. The patients were randomized into three groups and administered different drugs for the priming technique. Patients in group 1 received normal saline (control group). Patients in group 2 received rocuronium (0.06 mg/kg), and those in group 3 received cisatracurium (0.01 mg/kg) as a priming agent. Three minutes after injection of drugs, intubation doses of cisatracurium were administered (Group 1, 0.15 mg/kg; Groups 2 and 3, 0.14 mg/kg). Anesthesia was induced and maintained with propofol and remifentanil. Onset time, clinical duration, recovery index, recovery time, and total recovery time were measured by train of four monitoring. RESULTS: Onset time in the group 2 was significantly shorter than that of group 1 or 3 (P < 0.05). However, no significant differences in clinical duration, recovery index, recovery time, and total recovery time were observed among the three groups. CONCLUSIONS: Priming with rocuronium for 3 minutes resulted in significantly accelerated onset of cisatracurium. However, it did not affect the clinical duration and recovery profiles of cisatracurium.
