Effect of the Mixture of Pueraria lobata and Sorbus commixta Extract on the Alcohol-induced Hangover in Rats.
- Author:
Se Chul HONG
1
;
Ji Hyun YOO
;
Myeong Hwan OH
;
Hwan LEE
;
Young Sik PARK
;
Shanmugam PARTHASARATHI
;
Jong Dae PARK
;
Mi Kyung PYO
Author Information
1. International Ginseng & Herb Research Institute, Geumsan 312-804, Korea. pmk67@ginherb.re.kr
- Publication Type:Original Article
- Keywords:
Pueraiae lobata;
Sorbus commixta;
Alcohol dehydrogenase;
Acetaldehyde dehydrogenase;
Hangover
- MeSH:
Acetaldehyde;
Administration, Oral;
Alcohol Dehydrogenase;
Alcoholics;
Animals;
Cell Line;
Clone Cells;
Ethanol;
Humans;
Liver;
Metabolism;
Mice;
Oxidoreductases;
Pueraria*;
Rats*;
Sorbus*;
Survival Rate
- From:Natural Product Sciences
2015;21(2):98-103
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pueraiae Radix (PR), Pueratia Folium (PF) and Sorbus commixta (SC) mixture, namely GS-SP (PR (1)/PF (2)/SC (0.5): v/v/v) was developed as hangover-relieving elixir and its effects on alcoholic metabolism have been investigated. The enzymatic activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) of GS-SP was shown higher than those of single treatment with PR, PL, SC, and the positive control group (YM-808). The survival rate of mouse liver cell line NCTC clone 1469 in the presence of acetaldehyde was 30.6, 22.2, and 8.7% at the GS-SP dosage level of 50, 100, and 200 microg/mL respectively. Different concentrations of 50, 100 and 200 mg/kg of GS-SP showed efficient activity for ADH and ALDH than YM-808 in rat fed with 25% ethanol. The levels of blood alcohol and acetaldehyde after oral administration of 200 mg/kg of GS-SP showed efficient activity of 11.7% and 37% than those of YM-808. These results have been supported to the potential for GS-SP to serve as an excellent potential in providing hangover relief and liver protection.
