CT Radiologic Findings in Patients with Tuberculous Destroyed Lung and Correlation with Lung Function.
10.4046/trd.2011.71.3.202
- Author:
Jin Nyeong CHAE
1
;
Chi Young JUNG
;
Sang Woo SHIM
;
Byung Hak RHO
;
Young June JEON
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. jcy2475@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Tuberculosis, Pulmonary/complications;
Lung Diseases, Obstructive;
Tuberculosis;
Bronchiectasis
- MeSH:
Bronchiectasis;
Cicatrix;
Emphysema;
Forced Expiratory Volume;
Humans;
Korea;
Lung;
Lung Diseases;
Lung Diseases, Obstructive;
Pulmonary Atelectasis;
Respiratory Function Tests;
Retrospective Studies;
Smoke;
Smoking;
Thorax;
Tuberculosis;
Tuberculosis, Pulmonary;
Vital Capacity
- From:Tuberculosis and Respiratory Diseases
2011;71(3):202-209
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: A tuberculous destroyed lung is sequelae of pulmonary tuberculosis and causes various respiratory symptoms and pulmonary dysfunction. The patients with a tuberculous destroyed lung account for a significant portion of those with chronic lung disease in Korea. However, few reports can be found in the literature. We investigated the computed tomography (CT) findings in a tuberculous destroyed lung and the correlation with lung function. METHODS: A retrospective analysis was carried out for 44 patients who were diagnosed with a tuberculous destroyed lung at the Keimyung University Dongsan Hospital between January 2004 and December 2009. RESULTS: A chest CT scan showed various thoracic sequelae of tuberculosis. In lung parenchymal lesions, there were cicatrization atelectasis in 37 cases (84.1%) and emphysema in 13 cases. Bronchiectasis (n=39, 88.6%) was most commonly found in airway lesions. The mean number of destroyed bronchopulmonary segments was 7.7 (range, 4~14). The most common injured segment was the apicoposterior segment of the left upper lobe (n=36, 81.8%). In the pulmonary function test, obstructive ventilatory defects were observed in 31 cases (70.5%), followed by a mixed (n=7) and restrictive ventilatory defect (n=5). The number of destroyed bronchopulmonary segments showed a significant negative correlation with forced vital capacity (FVC), % predicted (r=-0.379, p=0.001) and forced expiratory volume in one second (FEV1), % predicted (r=-0.349, p=0.020). After adjustment for age and smoking status (pack-years), the number of destroyed segments also showed a significant negative correlation with FVC, % predicted (B=-0.070, p=0.014) and FEV1, % predicted (B=-0.050, p=0.022). CONCLUSION: Tuberculous destroyed lungs commonly showed obstructive ventilatory defects, possibly due to bronchiectasis and emphysema. There was negative correlation between the extent of destruction and lung function.
