Langerhans Cell Histiocytosis That Improved with Oral Isotretinoin Therapy.
- Author:
Ji Hyun CHOI
1
;
Hyun Chul SHIM
;
Ji Hye KIM
;
June Bum KIM
;
Mi Seon SHIN
;
Hyangjoon PARK
;
Jae Seung LEE
;
Ok Ja JO
;
Kye Yong SONG
Author Information
1. Department of Dermatology, Seoul Veterans Hospital, Seoul, Korea. ooops02@naver.com
- Publication Type:Case Report
- Keywords:
Isotretinoin;
Langerhans cell histiocytosis
- MeSH:
Abdomen;
Dermis;
Histiocytosis, Langerhans-Cell;
Humans;
Immunohistochemistry;
Isotretinoin;
Langerhans Cells;
Male;
Middle Aged;
Recurrence;
S100 Proteins;
Skin;
Ulcer
- From:Korean Journal of Dermatology
2010;48(10):893-897
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Langerhans cell histiocytosis (LCH) is a reactive disease in which abnormal Langerhans cells accumulate in various body sites. We report here on a 51-year-old male patient with LCH that was classified as single-system disease (restricted LCH). The skin lesions were a small, deep ulcer in the right inguinal area and multiple erythematous papules scattered on the lower abdomen, and the patient had these lesions for 1 year. The histopathologic examination revealed a dense histiocytic infiltration in the dermis, and most of the cells showed the characteristics of "LCH" cells. The immunohistochemistry for S-100 protein and CD1a complex all showed positive results. The patient was much improved after surgical excision of the inguinal ulcer and administering oral isotretinoin (20 mg daily) for 8 months, and there was no recurrence. We think retinoid is an effective treatment option for LCH, especially for single system disease.
