A Solitary Colonic Neurofibroma in a Patient without Neurofibromatosis.
- Author:
Kyeong Ok KIM
1
;
Byung Ik JANG
;
Hee Jung MOON
;
Sang Hoon LEE
;
Jun Young LEE
;
Kyu Hyung LEE
;
Si Hyung LEE
;
Youn Sun PARK
;
Jae Won CHOI
;
Jong Ryul EUN
;
Tae Nyun KIM
;
Heon Ju LEE
Author Information
1. Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. jbi@med.yu.ac.kr
- Publication Type:Case Report
- Keywords:
Neurofibromatosis;
Neurofibroma;
Colon;
S-100 protein
- MeSH:
Adult;
Asian Continental Ancestry Group;
Biopsy;
Colon;
Colon, Sigmoid;
Colonoscopy;
Humans;
Male;
Mucous Membrane;
Neurofibroma;
Neurofibromatoses;
Neurofibromatosis 1;
Polyps;
Porphyrins;
S100 Proteins
- From:Korean Journal of Gastrointestinal Endoscopy
2008;36(1):44-47
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neurofibromas are usually manifestations of neurofibromatosis type 1 (Nf1). There are usually multiple lesions on presentation. Solitary neurofibromas of the colon are extremely rare. A 34-year-old Asian male came to our hospital for non-specific findings, except for a complaint of loose stools for 2 months. A colonoscopy was performed. A sessile polyp 0.4 cm in diameter was detected at the sigmoid colon. Microscopically, a biopsy from the polyp showed proliferation of spindle cells in the mucosa, myxoid changes and infiltration of inflammatory cells. Immunohistochemical staining was positive for S-100 protein. The above morphological and immunohistochemical characteristics were consistent with a diagnosis of a neurofibroma. Only 13 cases of isolated colonic neurofibromatosis without Nf1 have been documented in the literature. We report this case as an isolated neurofibroma of the colon is even a rarer manifestation, and only three cases have been published in the clinical literature.
