An Experimental Study on Renal Functional Disturbance in Rabbits After Acute Ureteral Obstruction With Dynamic Gd-DTPA Enhanced MR Imaging.
10.3348/jkrs.1994.30.5.893
- Author:
Kyoung Ja SHIN
;
Eun Chul CHUNG
;
Chung Sik SIK RHEE
- Publication Type:Original Article
- MeSH:
Animals;
Gadolinium DTPA*;
Kidney;
Ligation;
Magnetic Resonance Imaging*;
Prognosis;
Rabbits*;
Ureter*;
Ureteral Obstruction*
- From:Journal of the Korean Radiological Society
1994;30(5):893-900
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the anatomic and functional change in acutely obstructed kidneys, and the probability of functional recovery after resolving the obstruciton. MATERIALS AND METHODS: There were 5 animal groups(6 rabbits in each group)-normal control group, 4 acute ureteral obstruction group. Each of the latter group was imaged with Gd-DTPA enhanced dynamic MR 2, 6, 24, and 48 hours after ligation of the left proximal urter, respectively. We compared the findings of dynamic MR imaging and histopathological findings. RESULTS: We could observe centripetal movement of dark band pattern which could be defined as 3 phasesrenal cortex, outer medulla, and inner medulla in normal rabbits. The appearance of the dark band pattern was delayed or absent in ureteral obstruction group with a linear relationship to the duration of the obstruction. CONCLUSION: Gd-DTPA enhanced MR can be used to differentiate acute obstructive nephropathy from other causes of nephropathy and foretell the prognosis of the obstruction.
