Analysis and Clinical Correlation of Bacteria Cultured from Patients with Inflammatory Acne.
- Author:
Jung Hyun HAN
1
;
Sook Jung YUN
;
Jee Bum LEE
;
Seong Jin KIM
;
Seung Chul LEE
;
Young Ho WON
Author Information
1. Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. yhwon@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Acne;
Antibiotic resistance;
Propionibacterium acnes;
Staphylococcus epidermidis
- MeSH:
Acne Vulgaris;
Bacteria;
Bacteria, Aerobic;
Clindamycin;
Drug Resistance, Microbial;
Enterobacter aerogenes;
Erythromycin;
Gentamicins;
Humans;
Klebsiella;
Propionibacterium acnes;
Skin Diseases;
Staphylococcus epidermidis
- From:Korean Journal of Dermatology
2011;49(8):676-682
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Acne is a common follicular inflammatory dermatosis affecting the pilosebaceous unit. The representative organism isolated from the acne lesion is Propionibacterium acnes, but other aerobic organisms, such as Staphylococcus epidermidis have also been isolated. The exact role of aerobic bacteria in the pathogenesis of acne remains controversial, but several reports have shown that these microorganisms are important in the development of acne lesions and affect acne severity by their involvement in the inflammatory process. OBJECTIVE: The purpose of this study was to investigate the clinical features associated with aerobic microorganisms isolated from inflammatory acne and to identify antibiotic resistance. METHODS: We examined the species of bacteria aerobically and anaerobically isolated from patients with inflammatory acne and determined the relationship between antimicrobial resistance of the isolated aerobic organisms and clinical characteristics in 186 patients. RESULTS: P. acnes was cultured in 40.86% of the patients. Enterobacter aerogenes (4.30%), S. capitis species (6.45%), S. aureus (3.76%), S. hominis (2.15%), Serraita marcescens (1.08%), Klebsiella oxitoca (1.08%), S. lugdunensis (1.08%), S. auricularis (0.54%), S. hyicus (0.54%), S. simulans (0.54%), and S. saprophyticus (0.54%) were also cultured. Among the aerobes isolated from lesions, S. epidermidis was the most common (43.0%) and showed higher resistance to gentamicin (57.5%), ampicilin (45.0%), erythromycin (40.0%), and clindamycin (30.0%) than previous reports. The disease duration in the S. epidermidis group resistant to gentamicin, erythromycin, ampicilin, and clindamycin was longer than that in the susceptible group. CONCLUSION: These results revealed the recent increase in antibiotic resistance of S. epidermidis in patients with acne. Antibiotic resistance of aerobes in patients with acne have a tendency to increase based on disease duration.
