Vitamin D Status and Bone Mineral Density in Children with Inflammatory Bowel Disease Compared to Those with Functional Abdominal Pain.
10.3346/jkms.2017.32.6.961
- Author:
Jenny SOHN
1
;
Eun Jae CHANG
;
Hye Ran YANG
Author Information
1. Melbourne Medical School, Univeristy of Melbourne, Melbourne, Australia.
- Publication Type:Original Article
- Keywords:
Bone Mineral Density;
Vitamin D;
Inflammatory Bowel Disease;
Children;
Asian
- MeSH:
Abdominal Pain*;
Asian Continental Ancestry Group;
Bone Density*;
Child*;
Colitis, Ulcerative;
Crohn Disease;
Female;
Gastrointestinal Diseases;
Head;
Hemoglobin A;
Humans;
Inflammatory Bowel Diseases*;
Phosphorus;
Risk Factors;
Vitamin D*;
Vitamins*
- From:Journal of Korean Medical Science
2017;32(6):961-967
- CountryRepublic of Korea
- Language:English
-
Abstract:
Low vitamin D has been implicated in reduced bone mineral density (BMD) in children with inflammatory bowel disease (IBD). Our study aimed to evaluate differences in serum 25-hydroxyvitamin D (25[OH]D) and total body less head (TBLH) BMD z-scores in children with Crohn's disease (CD), ulcerative colitis (UC), and those with abdominal pain-related functional gastrointestinal disorder (AP-FGID) as the control group. We also examined the correlation between serum 25(OH)D and TBLH BMD z-score, and factors that affect each of these parameters. A total of 105 children were included and divided into 3 groups: AP-FGID (n = 45), CD (n = 43), and UC (n = 17). Among the 3 study groups, TBLH BMD z-scores were found to be significantly different (0.5 ± 0.8 in CD vs. 0.1 ± 0.8 in UC vs. −0.1 ± 1.1 in FGID; P = 0.037), despite similar levels of serum 25(OH)D. Within each study group, correlation between serum 25(OH)D and TBLH BMD z-score was not observed. Factors found to affect the TBLH BMD z-score were sex (P = 0.018), age (P = 0.005) and serum hemoglobin (P = 0.041), while factors influencing serum 25(OH)D were sex (P = 0.018), CD with reference to AP-FGID (P = 0.020), and serum phosphorus (P = 0.018). Based on our results, vitamin D is a relatively small contributor to bone loss in pediatric IBD and clinicians should consider female sex, older age, and low hemoglobin as risk factors for low BMD in children with IBD.
