The clinical analysis of hyperglycemic controls with four times daily administration of insulin on diabetes in pregnancy.
- Author:
Ho LEE
1
;
So Young KIM
;
Jin Kyo LEE
;
Eun Taek LEE
;
Jin Ho JANG
;
Jeong Hun LEE
;
Jee Hyun PARK
;
Sung Ook HWANG
;
Eun Seop SONG
;
Seung Kwon KOH
;
Moon Whan IM
;
Woo Young LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Inha University, Inha University Hospital, Korea. wylee4723@hanmail.net
- Publication Type:Original Article ; Comparative Study
- Keywords:
Diabetes;
Insulin;
Hyperglycemic control
- MeSH:
Capillaries;
Female;
Glucose;
Humans;
Insulin Lispro;
Insulin*;
Pregnancy*
- From:Korean Journal of Obstetrics and Gynecology
2005;48(2):391-400
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine whether administrating insulin four times daily, compared to 1-3 times daily, improves maternal and perinatal outcomes of diabetes. METHODS: From August 1998 to April 2004, the 14 pregnant diabetic women were treated with four times daily administration of NPH and insulin-lispro and 15 pregnant diabetic women were treated with 1-3 times daily administration of Mixtard (30% RI, 70% NPH) or NPH. We compared the maternal and fetal complications between two groups. The goals for therapy are to achieve and maintain normoglycemia (premeal whole blood capillary glucose levels of less than 90 mg/dL and 1-hour after-meal levels of less than 120 mg/dL). RESULTS: The pregnant diabetic women who were treated with four times daily administration of NPH and Insulin lispro, instead of 1-3 times daily administration of Mixtard or NPH, resulted in better maternal and fetal outcome. But there was no significant difference between two groups statistically. CONCLUSION: This study reveals that this four times daily administration of NPH and insulin-lispro protocol achieved the glucose target level without maternal hypoglycemic events and helped to reduce the perinatal complications in pregnant diabetic women.
